The pituitary hormone-releasing or releasing-inhibiting hormones of the hypothalamus are synthesised within the nuclei of the hypothalamus (1ΓÇô4) and transported to the median eminence from where they travel to the anterior pituitary via the dense capillary network and the long portal veins. These hypothalamic factors occupy specific receptors on pituitary cells and lead either to the release or inhibition of the pituitary hormones.